The creation of Austin’s first medical school (Dell Medical School) presented an opportunity to leverage it as a foundation for an Innovation District with global appeal. Upstream was engaged by the city’s Chief Innovation Office to create a vision for the district and plan for realizing it. Through secondary research, we discovered five key barriers to innovative ecosystems, which included, mitigating risk, access to talent, capital and ideas, exposure to markets, aligning to purpose and rewarding risk-taking. We then benchmarked how well other innovation zones addressed these barriers to identify underserved innovator needs that Austin’s Innovation District could fulfill.